Naltrexone - complex treatment of alcohol dependence. It is also attributed to the prevention of the pharmacological effects of exogenous opioids and the maintenance of a non-opioid state in patients with opioid dependence.
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Product Description
Naltrexone is used as an auxiliary medicine after the withdrawal of opioid analgesics in the treatment of opioid addiction and alcoholism.Competitively blocks the binding of agonists or displaces them from opiate receptors.Reduces or removes symptoms caused by/in the introduction of opiates.The greatest affinity is for the mu and kappa receptors.
Safety information
Mode of application
Intake.Treatment of alcoholism: 50 mg once a day for 12 weeks.
Therapy of drug dependence begins only after a 7-10-day abstinence from the use of opioids, confirmed by a provocative test and urinalysis.The initial dose is 25 mg, for 1 hour the patient's condition should be monitored, in the absence of the withdrawal syndrome, the remainder of the daily dose is administered.Naltrexone is given 50 mg every 24 hours.
Contraindications
Hypersensitivity, the condition of withdrawal from the background of opioid dependence, a positive test for the presence of opioids in the urine, acute hepatitis, hepatic insufficiency.
Side effects
From the nervous system and sense organs: anxiety, nervousness, fatigue, general weakness, restless sleep, nightmarish dreams, headache, dizziness, blurred vision, confusion, hallucinations, fainting, CNS depression, irritability, anxiety, drowsiness, disorientation, Ringing and feeling of stuffiness in the ears, pain and burning sensation in the eyes, photophobia.
Cardio-vascular system and blood: chest pain, increased blood pressure, palpitations, tachycardia,nonspecific ECG changes, phlebitis, lymphocytosis.
On the part of the respiratory system: cough, hoarseness, nasal congestion, rhinorrhea, sneezing, bronchial obstruction, difficulty breathing, shortness of breath, epistaxis, dryness in the throat, increased separation of mucous sputum, sinusitis, pharyngitis, nasopharyngitis.
On the part of the intestine: nausea and / or vomiting, abdominal pain, diarrhea or constipation, frequent defecation, gastrointestinal upset, flatulence, dry mouth, anorexia, decreased / increased appetite, taste distortion, erosive and ulcerative gastrointestinal lesions, aggravation Symptoms of hemorrhoids, increased activity of liver enzymes.
From the musculoskeletal system: arthritis, joint pain, joint stiffness, back pain, pain in the limbs, muscle pain, muscle spasm, muscle twitching, stiffness in the muscles.
On the part of the genitourinary system: discomfort with urination, increased frequency of urination, edematous syndrome, sexual disorders in men.
Allergic reactions: skin rash, itching, skin hyperemia (including face hyperemia),
Arimidex, which is anastrozole - is prescribed for women in the post-menopausal period of widespread breast cancer. As exception can be patients with estrogen negative cancer if only earlier they didn't have a positive clinical answer on tamoxifen. For adjuvant therapy at the patients in the post-menopausal period having the positive indicators of receptor of hormone, an invasive estrogenpositive breast cancer at early stages. For adjuvant therapy at patients in a post-menopausal period who had adjuvant treatment by tamoxifen within 2-3 years, estrogen of a positive breast cancer at early stages.
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The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
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