Tofranil is a drug that is very sensitive to the form of depressive disorder (glycoem depressive disorder, depressive phase of bipolar infections, depressive disorder, migraine, depression, dysthymia;
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Product Description
Tofranil is one of the main representatives of tricyclic antidepressants. Due to its high efficiency and clinical value, it has been used since the 50s until today. In addition to antidepressant has a stimulating effect. It is assigned for depressive states of various etiologies, including: asthenodepressive syndrome, depression (endogenous, involutional, climacteric, reactive, alcoholic), depressive states in psychopathy and neuroses, panic disorder, functional enuresis in children.
Safety information
Tofranil is assigned usually for an oral intake (after mealth), starting at 0.75-0.1 g per day, then gradually the dosage is increased (daily by 0.025 g) and finally comes to 0.2-0.25g per day. With the onset of an antidepressant effect, increasing the dose is not recommended. The treatment - on average - lasts 4-6 weeks, then the dose is gradually reduced and the treatment is switched to maintenance therapy (with 0.025 g 1-4 times a day).
The constant medical supervision of patients with suicidal tendencies is mandatory. During the treatment with tofranil, all alcoholic beverages are restricted. It is recommended to control the cellular composition of peripheral blood and liver function. During the treatment of patients with diabetes, the correction of doses of oral hypoglycemic drugs is necessary. During the initial period of therapy, we must abandon the management of vehicles and carry out potentially hazardous activities.
Contraindications: hypersensitivity, hepatic-renal failure, IHD, tachycardia, congestive heart failure, early post-infarction period, propensity to convulsions, schizophrenia, epilepsy, glaucoma, prostate adenoma, bladder atony, pregnancy, children's age (up to 6 years).
Side effects
On the part of the nervous system and sensory organs: headache, dizziness, excessive sedation, paresthesia, tremor, convulsions, dysarthria, impaired coordination of movements, sleep disturbance, agitation, hallucinations, disruption of accommodation.
On the part of the cardiovascular system and blood system (hematopoiesis, hemostasis): tachycardia, arrhythmia, orthostatic hypotension, leukocytosis or leukopenia, agranulocytosis.
On the part of the digestive tract: dryness in the oral cavity, constipation, hepatitis.
On the part of the genitourinary system: delay urination, gynecomastia, galactorrhea, decreased libido, impotence.
Other: weight gain, photosensitivity, hair loss, fever, hyper-hidrosis.
In case of an arterial hypertension of Atacand causes dose-dependent long lowering of arterial pressure. Anti-hypertensive action happens due to decrease in system peripheric resistance without reflex increase in heart rate. Instructions on serious or strengthened hypotension after taking of the first dose or Withdrawal Effect after termination of treatment are absent.
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Claritin prevents development and facilitates the course of allergic reactions. Possesses antiallergic, antipruritic, antiexudative action. Reduces permeability of capillaries, controls oedemata of tissues, removes spasms of smooth muscles. It is prescribed at allergic rhinitis, conjunctivitis, pollinosis, urticaria fever, angioedema, pruritic dermatosis; pseudo-allergic reactions, caused by release of histamine; allergic reactions at stings of insects.
Dulcolax - purgative. Causes irritation of the receptor of bowels, exerts direct impact at mucous membrane of intestines, strengthening its peristaltics and increasing secretion of slime in a large intestine. It is effective at hypotonic and colonic inertia for regulation of fecal matter. Sometimes it is taken at preparation for surgeries, instrumental examinationand and radiological researches.
A tricyclic antidepressant with a relatively short latency period. It has almost no sedative effect. therapeutical indications include: depressive phases of a manic-depressive psychosis, all other forms of endogenous depression (reactive and neurotic). In combination with amitriptyline it is used for depressions that occurred during treatment with reserpine. In combination with neuroleptics, it is used in the treatment of depression that developed during treatment of schizophrenic psychoses.
